Everywhere in the pharma industry I see one set of macros to do safety
reporting and a jumble of other macros to do efficacy reporting.
Things could be made better by extending the safety reporting macros
to do efficacy reporting as well. This would make things a lot
simpler. It IS possible and I have done this (but I had to reorganise
the code in the macros first and do a minor redesign). I recently did
this with my %unistats macros as you can see below.

http://www.datasavantconsulting.com/roland/Spectre/freqsept.html

It can also be done for proc glm calls (I have already done this) or
for any other stats procedure you need to call.

If you use this technique then at last you can have consistency of
layout and integrated delivery of both safety and efficacy reports
because it will all be within the one system. Plus it should cut out
most of the time for the writing and maintenance of the efficacy
reporting macros.